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Technical ContributionsThe major technology contribution made by Dr. Hao-Li Liu includes: (1) Surgical Navigation-Guided Focused Ultrasound Application for Blood-Brain Barrier Opening and Clinical Treatment: Focused on the development of focused ultrasound technology for opening the blood-brain barrier. Successfully overcame the transmission barriers of ultrasound in the brain by developing a surgical navigation-guided technique that precisely focuses ultrasound energy at a depth of 5-10 centimeters beneath the skull. This technology is applied to blood-brain barrier opening and drug therapy. In 2020, it was reported by Nature Reviews Neurology as one of the three major ultrasound-based brain drug delivery techniques. In 2021, Science Advances published the clinical safety test results of this technology, garnering international attention and invitations to present the findings. This technology received the Outstanding Research Scholar Lecture award from the International Society for Therapeutic Ultrasound, recognizing its contribution to ultrasound-mediated brain drug release.(2) Ultrasound Neuromodulation for Epilepsy Treatment and Advancement of Clinical Trials: Developed a technology utilizing ultrasound for neuromodulation, successfully demonstrating its inhibitory effects on epileptic seizures in animal models. In collaborative research with Stanford University, it was first confirmed that ultrasound has a longlasting inhibitory effect on chronic epilepsy and possesses neuroprotective mechanisms. These findings have been published in several top-tier biotechnology journals and have received approval from the Ministry of Health and Welfare to conduct safety and efficacy clinical trials in epilepsy patients, showcasing a globally leading perspective.(3) Design and Development of Focused Ultrasound Phased Array Systems: Innovatively designed a focused ultrasound phased array system, breaking through the limitations of traditional single-frequency ultrasound. This system utilizes hundreds of independently driven elements to achieve large-scale electronic focusing and scanning, significantly enhancing clinical applicability. The technology was published in the IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control and was highlighted by IEEE Spectrum and Fortune as a significant breakthrough in ultrasound technology.(4) Ultrasound-Mediated Brain Gene Delivery for Treatment: Developed a technology for gene delivery to the brain using ultrasound, demonstrating higher gene expression efficiency compared to traditional methods. This technology has been published in several top-tier biotechnology journals and applied to the treatment of Parkinson%u2019s disease and Huntington%u2019s disease. The research was selected as a cover story for journals, highlighting its high clinical applicability.(5) Multi-Frequency Ultrasound Technology Enhancing Stem Cell Differentiation: Developed dual-frequency ultrasound technology that overcomes the limitations of singlefrequency ultrasound, improving the application efficiency of ultrasound in stem cell differentiation and physical therapy. This technology has been published in several top-tier biotechnology journals, demonstrating superior performance in the differentiation of neural cells and tumor stem cells.Future Prospects of ResearchDr. Hao-Li Liu%u2019s postdoctoral experience at Harvard University made him deeply aware of the importance of rigorous %u7b2c%u4e09%u5341%u4e00%u5c46%u6771%u5143%u734e%uff0e%u79d1%u6280%u985e%u734e%u751f%u91ab / %u8fb2%u696d%u79d1%u6280